As demonstrated by comparative pharmacokinetic studies, Silipide® represents the most absorbable oral form of silybin known.
In rats, after oral administration of 200 mg/kg of silybin, the plasma levels of silybin and its conjugated metabolites were below the analytical detection limit, while, after oral administration of Silipide® (200 mg/kg as silybin) the plasma levels of silybin (free and total) were easily measurable, being well absorbed within minutes when in phytosomal form(3).
In another study on rats, the pharmacokinetic of Silipide® and silymarin were compared(4). Silybin given as Silipide®at 200 mg/kg was detectable in the plasma within minutes, peaked after 1 h, and its plasma levels remained elevated for over 6 hours. The AUC value of free silybin after Silipide® intake was more then 400% higher than after intake of silymarin. Silipide® was also shown to rapidly reach the liver, cross the liver cells, and appear in the bile within 2 h. The amount of silybin reaching the bile after Silipide® dosing was at least 6.5 times higher than that from non-complexed silybin administered as silymarin.
The pharmacokinetics of Silipide® in healthy human subjects showed that complexation with phosphatidylcholine improved the oral bioavailability of silybin 4.6 fold compared with silymarin, presumably because of a facilitated passage across the gastrointestinal mucosa(5).Expand Bibliography
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